Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction

Duke University

Status: Completed

Conditions: Shortness of Breath; Chest Pain

Treatments: Diagnostic Test: Echocardiogram

Study type: Interventional

Funder types: Other

Identifiers

NCT06927973

Pro00117015

Details and patient eligibility

About

The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart (heart failure with preserved ejection fraction or HFpEF).

Enrollment: 30 patients

Sex: All

Ages: 50+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinically indicated exercise stress echo for the evaluation of exertional dyspnea or chest pain
• Age ≥50 years

Exclusion criteria

• Known history of HFpEF
• LVEF <50% on baseline echo study
• History of hypertrophic cardiomyopathy, amyloidosis, or pulmonary arterial hypertension, severe right ventricular dysfunction and severe valvular disease based on chart review or baseline echo study
• History of organ transplant (heart, kidney, liver, lungs)
• Severe pulmonary disease requiring ambulatory oxygen therapy
• End-stage renal disease requiring long-term renal replacement therapy
• Decompensated liver disease
• Conditions that prevent accurate assessment of E/e' ratio (mitral prosthetic valve, severe mitral annular calcification)
• Plan to use echo contrast agent during stress study (i.e. contrast agent needed for baseline study)
• Patients from outside Duke health system with no plan for long-term care at Duke

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

30 participants in 1 patient group

Enrolled subjects undergoing clinical stress echocardiogram

Experimental group

Description:

The enrolled subject will undergo their clinically indicated stress echocardiogram study for chest pain or shortness of breath. At the conclusion of the clinical study 4 additional echo images will be obtained for research purposes.

Treatment:

Diagnostic Test: Echocardiogram