Leveraging the Emergency Department to Engage African American Women in HIV Pre-Exposure Prophylaxis (IWPrEP)

The University of Texas System (UT)

Status: Completed

Conditions: HIV Infections

Treatments: Behavioral: Usual Care; Behavioral: iPrEP

Study type: Interventional

Funder types: Other

Identifiers

NCT03930654

HSC-MS-16-0892

Details and patient eligibility

About

African American (AA) women are more vulnerable to HIV infection than other women. Truvada, when used as pre-exposure prophylaxis (PrEP), is one of the most effective approaches for HIV prevention; however, PrEP use among AA women remains low and has not responded to traditional interventions. This study proposes for the first time an innovative computer-based motivational intervention, increasing PrEP uptake (iPrEP), which couples motivational messages woven into a traditional survey to raise awareness of risky sex and substance use behaviors.

Enrollment: 40 patients

Sex: Female

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Current HIV negative status (based on ED' HIV test outcome)
• Condomless sex in the last 3 months
• Substance use in the last 3 months
• HIV testing during ED visit (usual care)
• Has a non-emergent health condition
• Has a working mobile device with them

Exclusion criteria

• Ineligible for PrEP (see eligibility criteria to the right)
• Assigned male at birth
• An HIV positive status
• Currently taking medication that are known contraindications for PrEP (brand name: Truvada)
• Currently on PrEP

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

iPrEP Intervention

Experimental group

Description:

iPrEP Intervention: * Women will receive the iPrEP intervention on an iPAD Air tablet device * iPrEP serves a dual role as a data collection instrument and an intervention--the survey incorporates brief, informational messages into a traditional survey instrument * iPrEP uses qualitative themes * iPrEP is divided into sections addressing factors with historical success at predicting pre-exposure prophylaxis (PrEP) adherence * Scales chosen to measure themes and sections were retained from the original HIV Prevention Trials Network (HPTN) 073 instrument * Scales were modified (in some cases) for cultural competency and tailoring to women

Treatment:

Behavioral: iPrEP

Behavioral: Usual Care

Usual Care

Active Comparator group

Description:

Control Intervention: * Women will receive usual care * Usual care includes an assessment visit with an emergency department (ED)-assigned social worker who specializes in substance use * Social worker will offer a list of substance abuse treatment referral agencies

Treatment:

Behavioral: Usual Care