Levetiracetam (Keppra) to Improve Chronic Aphasia in Post-stroke Patients.

Kessler Foundation

Status and phase: Unknown; Phase 1

Conditions: Stroke; Aphasia

Treatments: Drug: Wait first, then levetiracetam; Drug: Levetiracetam first, then wait

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00227461

AMBarrett1

none applicable

Details and patient eligibility

About

The study investigates the possibility that levetiracetam may improve the symptoms of chronic post-stroke aphasia.

Full description

In the study, 50 post-stroke subjects with aphasia will take levetiracetam and we will evaluate their speech, language, and memory in an ABAB design.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stroke
• Aphasia
• Can give consent

Exclusion criteria

• Renal failure
• Pregnancy
• Other neurological condition

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

50 participants in 2 patient groups

Wait control

Other group

Description:

Levitiracetam is started after a delay, with dosage and administration as described below.

Treatment:

Drug: Levetiracetam first, then wait

Treatment first

Experimental group

Description:

Levitiracetam is started immediately after baseline data is collected; dosage and administration as described below.

Treatment:

Drug: Wait first, then levetiracetam