Levobupivacaine on Heart Rate Variability (HRV) in Spinal Anesthesia

National Taiwan University

Status and phase: Unknown; Phase 4

Conditions: Spinal Anesthesia

Treatments: Drug: bupivacaine, levobupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT00974961

200903050M

Details and patient eligibility

About

The purpose of this study is to compare if the effect of levobupivacaine on autonomic nervous system smaller than that of bupivacaine.

Full description

Obtain the heart rate variability (in means and standard deviation, including the high frequency, low frequency and its ratio) data of before and after spinal anesthesia with ECG (and Heart Rate Variability Analyzer) in 2 groups. Meanwhile, record the blood pressure on each subject.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Indicated for spinal anesthesia

Exclusion criteria

• Allergic reaction to local anesthetics
• Coagulopathy
• Severe spinal deformity
• Cardiac diseases
• Metabolic diseases (such as DM, thyroid or adrenal diseases)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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70 participants in 2 patient groups

Levobupivacaine

Active Comparator group

Description:

Lumbar puncture with Levobupivacaine for spinal anesthesia

Treatment:

Drug: bupivacaine, levobupivacaine

Bupivacaine

Active Comparator group

Description:

Lumbar puncture with Bupivacaine for spinal anesthesia

Treatment:

Drug: bupivacaine, levobupivacaine