Lexical Priming by Music in Alzheimer's Disease and Healthy Aging (PriMus)

Centre Hospitalier Universitaire de Saint Etienne

Status: Terminated

Conditions: Alzheimer Disease

Treatments: Other: Music Experience Questionnaire; Other: Questionnaires; Other: Implicit tasks memory; Other: Exposure to familiar songs

Study type: Interventional

Funder types: Other

Identifiers

NCT03342326

2017-A02686-47 (Other Identifier)

1708117

Details and patient eligibility

About

While verbal memory is quickly reached in the wake of Alzheimer's disease, the musical memory remains preserved until a late stage of the disease. This observation encouraged the development of music-based therapies in the management of neurocognitive and behavioral disorders that characterize Alzheimer's disease. In order to develop rehabilitation programs that effectively target cognitive functions to stimulate, it is necessary to understand the mechanisms underlying this beneficial effect of music on cognition.

Full description

The investigators study the stimulation by the song, material integrating language and music, and having an autobiographical value. The investigators measure the lexical priming capacity of the song, that is, its ability to activate and maintain lexical and semantic representations, which are threatened with alteration in the course of the disease.

This lexical priming effect by song is measured in patients with mild Alzheimer's disease and healthy volunteers during a single test session. In the first phase of the session, participants are exposed to familiar songs, presented in sung, spoken or instrumental form, whose popularity they evaluate. In the second phase, they perform two implicit memory tasks: a trigram completion task and a lexical decision task. These tests measure the facilitation of the processing of words evoked by songs in relation to words unrelated to songs, reflecting a "long-term" memory update of mnemic traces of primed words.

Enrollment: 58 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for patients :

• Presence of diagnostic criteria for Alzheimer's disease
• Age ≥ 65 years
• MMSE (Mini-mental state Examination) ≥ 20

Exclusion Criteria for patient :

• Unstable clinical presentation or language presentation in the foreground
• Cognitive disorder of etiology different from that of Alzheimer's disease

Inclusion Criteria for volunteers :

• Age ≥ 18 years
• Absence of neurological or psychiatric antecedents
• For those aged 65 or over: MMSE (Mini-mental state Examination) greater than or equal to 27; non-pathological performance against the 5 words of Dubois and the verbal fluency test.

Exclusion Criteria for volunteers :

• Visual or auditory disorders insufficiently corrected
• Oral or written expression in French insufficient to carry out tests
• Consumption of psychotropic drugs not stabilized

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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58 participants in 2 patient groups

patient with Alzheimer's Disease

Other group

Description:

1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.

Treatment:

Other: Exposure to familiar songs

Other: Music Experience Questionnaire

Other: Implicit tasks memory

healthy volunteer

Other group

Description:

1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not. 4. For volunteer over 65 years : Mini Mental State Examination, 5 words by Dubois and fluence verbal test

Treatment:

Other: Exposure to familiar songs

Other: Music Experience Questionnaire

Other: Implicit tasks memory

Other: Questionnaires