LH/FSH, Testosterone, Prolactin, and Ferritin in PCOS Patients in Jordan (PCOS patients)

Future University in Egypt

Status: Completed

Conditions: PCOS (Polycystic Ovary Syndrome)

Treatments: Diagnostic Test: Serum levels of LH, FSH, testosterone, prolactin, and ferritin

Study type: Observational

Funder types: Other

Identifiers

NCT07112768

Al-Ahliyya Amman University 1

Details and patient eligibility

About

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder impacting women of reproductive age. Characterized by chronic anovulation, hyperandrogenism, and the presence of multiple small ovarian cysts. Despite its widespread occurrence, a comprehensive study particularly within the Jordanian population remains limited. Aim of the study: The study aimed to assess the serum levels of the Luteinizing hormone (LH), Follicle stimulating hormone (FSH), LH/FSH ratio, Testosterone, Prolactin, and Ferritin in Jordanian women diagnosed with PCOS

Full description

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder impacting women of reproductive age. Characterized by chronic anovulation, hyperandrogenism, and the presence of multiple small ovarian cysts. Despite its widespread occurrence, a comprehensive study particularly within the Jordanian population remains limited. Aim of the study: The study aimed to assess the serum levels of the Luteinizing hormone (LH), Follicle stimulating hormone (FSH), LH/FSH ratio, Testosterone, Prolactin, and Ferritin in Jordanian women diagnosed with PCOS. Materials and Methods: A total 80 women aged between 20-41 years with confirmed PCOS diagnosis and 60 age matched healthy control were enrolled. Participant completed a structured questionnaire and provided informed consent .Blood samples were collected for measurement of LH, FSH, LH/FSH ratio, testosterone, prolactin, and ferritin levels using standardized laboratory protocol. Results: There were significant differences between the PCOS and control groups in the levels of LH, FSH, LH/FSH ratio, total testosterone, prolactin, and ferritin (p<0.05 for all). Specifically, the PCOS group showed higher levels of LH, testosterone, prolactin, and ferritin, while FSH levels were significantly lower. Additionally, positive correlations were observed between LH and testosterone, FSH and prolactin, and between ferritin and both LH and the LH/FSH ratio. Conclusions: The altered hormonal and biochemical profiles observed in PCOS patients emphasize the role of these biomarkers in diagnosing and understanding the pathophysiology of PCOS. These findings could support better clinical management and inform future research, particularly in the Jordanian patients.

Enrollment: 140 patients

Sex: Female

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 20-45 PCOS diagnosed females Jordanian

Exclusion criteria

• younger than 20 older than 45 Non -Jordanian

Trial design

140 participants in 2 patient groups

Control group

Description:

control group (n=60), consisting control women aged 22-41 years

Treatment:

Diagnostic Test: Serum levels of LH, FSH, testosterone, prolactin, and ferritin

PCOs group

Description:

the study group (n=80), comprising women aged 20 to 41 years who were diagnosed with PCOS based on the Rotterdam criteria (2003) as assessed by obstetric and gynecology specialist

Treatment:

Diagnostic Test: Serum levels of LH, FSH, testosterone, prolactin, and ferritin