LH Hormone Pulsation in the Luteal Phase in GnRH Antagonist IVF Cycles Triggered by GnRH Agonist for Final Oocyte Maturation

Rambam Health Care Campus

Status: Completed

Conditions: Infertility

Study type: Observational

Funder types: Other

Identifiers

NCT02449642

protocol1

Details and patient eligibility

About

Monitoring the LH pulsatility during the Luteal phase in GnRH antagonist IVF cycles triggered by GnRH agonist for final oocyte maturation.

Full description

About two decades ago the GnRH antagonist has been used in IVF cycles to prevent premature LH surge. In recent review GNRH antagonist has been found comparable to GnRH agonist in term of live birth rate but with reduced risk of OHSS. another advantage of using GnRH antagonist is the ability to use GnRH agonist for final oocyte maturation which has been shown to nearly eliminate the risk of OHSS. The exact mechanism of this risk reduction is still unknown.

Our aim is to do a frequent blood tests every 20 minutes for 6 hours duration in the day of ovum pick up or the day of embryo transfer to measure the level of LH, estradiol and progesterone in women triggered with GnRH agonist for final oocyte maturation.

Enrollment: 10 patients

Sex: Female

Ages: 18 to 42 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age: 18-42 years old BMI < 32 kg/m2

Exclusion criteria

• Hypogonadotropic hypogonadism

Trial design

10 participants in 2 patient groups

group 1

Description:

group 1 include 10 women in which blood tests will be taken on the day of oocyte pick up

group 2

Description:

group 2 include 10 women in which blood tests will be taken on the day of embryo transfer