Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL)

The Mentor Initiative

Status: Completed

Conditions: Anemia; Malaria, Falciparum

Treatments: Device: Insecticide treated wall lining

Study type: Interventional

Funder types: Other

Identifiers

NCT02448745

LiberiaDL

Details and patient eligibility

About

A cluster-randomized control trial will study the effect of insecticide-treated wall lining on malaria transmission in Bomi County, Liberia. Half of the villages enrolled in the study will receive insecticide-treated wall lining covering their walls and ceilings in addition to long-lasting insecticidal nets, while the other half will be protected by existing long-lasting insecticidal nets.

Full description

Long-lasting insecticidal nets (LLINs) are the established vector control product for malaria control. In Bomi County Liberia, LLINs have been distributed but malaria prevalence in children under 5 remains high, with prevalence in study villages found to be 42% in April 2014. The major malaria vector species are resistant to pyrethroid insecticides approved for use in LLINs, and new control measures with non-pyrethroid active ingredients may protect the population.

Enrollment: 6,317 patients

Sex: All

Ages: 2 to 59 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Child resides in village
• Child presents with parent or guardian

Exclusion criteria

• Child or guardian has history of Ebola exposure
• Child has 3 symptoms of Ebola

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

6,317 participants in 2 patient groups

Control

No Intervention group

Description:

21 clusters composed of one or more villages with a total number of 30 to 70 children under 5 years old. Routine distribution of long-lasting insecticidal nets is the only malaria control intervention.

Intervention

Experimental group

Description:

21 clusters composed of one or more villages with a total of 30 to 70 children under 5 years old. Routine distribution of long-lasting insecticidal nets is available and in addition insecticide treated wall lining is installed in all sleeping areas with homeowner consent. All 4 walls and the ceiling are covered with lining.

Treatment:

Device: Insecticide treated wall lining