Lidocaine and Analgesia After Laparoscopic Cholecystectomy

Larissa University Hospital

Status: Completed

Conditions: Postoperative Pain; Opioid Consumption

Treatments: Drug: Lidocaine; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03620591

UHL27823/06/28/2018

Details and patient eligibility

About

The purpose of this study is to evaluate how effective is the intraoperative use of lidocaine to attenuate postoperative pain and opioids consumption after laparoscopic cholecystectomy

Full description

Acute postoperative pain may predict the development of chronic pain.Recently, the analgesic effect of lidocaine, as a part of a multimodal analgesia, has been evaluated in many studies. They have shown that lidocaine may have a role in the postoperative pain management, as an adjunct.

Acute postoperative pain after laparoscopic cholecystectomy is complex in nature. Postoperative pain is the main complaint and the primary reason for delay discharge after laparoscopic cholecystectomy.The study includes patients undergoing laparoscopic cholecystectomy.

Enrollment: 98 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status I-II
• Age ≥ 18 years old
• BMI ≤ 35

Exclusion criteria

• Allergy in local anesthetics
• History of liver, kidney or heart failure
• Existence of chronic pain history or daily analgesics
• Psychiatric disorders
• Inability to understand pain assessment

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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98 participants in 2 patient groups, including a placebo group

Lidocaine

Active Comparator group

Description:

Intraoperative administration of lidocaine to patients undergo laparoscopic cholecystectomy. Prior induction to anesthesia, lidocaine bolus 1.5 mg / kg will be administered to the lidocaine group and then patients will be connected to a continuous 2 mg / kg / h administration of lidocaine until the end of the procedure.

Treatment:

Drug: Lidocaine

Placebo

Placebo Comparator group

Description:

Intraoperative administration of normal saline to patients undergo laparoscopic cholecystectomy.

Treatment:

Drug: Placebo