Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation

Derince Training and Research Hospital

Status: Completed

Conditions: Lidocaine

Treatments: Drug: Nebulized Lidocaine; Drug: Iv Lidocaine

Study type: Observational

Funder types: Other

Identifiers

NCT06107543

DerinceTRH-EAtli-001

Details and patient eligibility

About

Direct laryngoscopy and endotracheal intubation procedure stimulate the sympathetic nervous system, causing catecholamine release into the circulation and consequently hemodynamic changes.There are many studies showing that lidocaine is used intravenously to suppress the sympathetic response to laryngoscopy and endotracheal intubation. Nebulized lidocaine is often used to provide upper airway local anesthesia in fiberoptic guided awake intubation.

In this study, the researchers aimed to compare the results of using intravenous lidocaine and nebulized lidocaine to suppress the hemodynamic response caused by laryngoscopy and endotracheal intubation retrospectively.

Researchers' hypothesis; Nebulized lidocaine administration is more effective than intravenous lidocaine administration in suppressing the hemodynamic response due to laryngoscopy and endotracheal intubation in patients under general anesthesia.

Full description

2% lidocaine drug to suppress the hemodynamic response due to laryngoscopy and endotracheal intubation; patients administered intravenously will be evaluated in one group, and patients administered inhaled through a nebulizer will be evaluated in another group.

Nebulized lidocaine in the researchers' clinic; it is administered by adding 2% lidocaine + physiological saline to a nebulizer and inhaling for 3-5 minutes in the presence of 4-6 liters/minute of oxygen.

Preoperative examination forms and intraoperative follow-up forms of the patients included in the study will be examined by the researchers. The dose of lidocaine applied and the method of administration will be recorded. In addition, the agents used in anesthesia induction (fentanyl, propofol, rocuronium bromide, etc.) and the hemodynamic changes of the patients (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure,oxygen saturation) will be recorded.

Enrollment: 94 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients over the age of 18 and under the age of 80 who underwent surgery under general anesthesia

Exclusion criteria

• Patients under the age of 18 and over the age of 80
• Patients who are not operated under general anesthesia

Trial design

94 participants in 2 patient groups

Intravenous lidocaine

Description:

Patients who received lidocaine intravenously before induction of anesthesia will be considered in this group.

Treatment:

Drug: Iv Lidocaine

Nebulized lidocaine

Description:

Patients who received lidocaine by inhalation with a nebulizer before induction of anesthesia will be considered in this group.

Treatment:

Drug: Nebulized Lidocaine