Lidocaine Infusion for Postthoracotomy Pain Syndrome (LIPPS)

Guangzhou First People's Hospital

Status: Unknown

Conditions: Thoracic Surgery, Video-Assisted; Chronic Pain; Lidocaine; Pain, Postoperative

Treatments: Drug: Lidocaine; Drug: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT03666299

GZFPH-2018-114

Details and patient eligibility

About

This study seeks to investigate lidocaine infusion to reduce postthoractomy pain syndrome after thoracic Surgery

Full description

Postthoracotomy pain syndrome (PPS) is defined as a persistent and/or recurrent pain or burning sensation along the thoracotomy scar at 3 months after surgery. The pain is very significant, given that 3 to 5% of postthoractomy patients report it as being severe, and approximately 50% of patients report limitations in their activities of daily living. Little is known about the origin of this pain, but it seems that the intensity of acute postoperative pain is the best predictor of it. Lidocaine infusion could be a possible approach to reducing the prevalence of PPS. Recently, a meta-analysis concluded a modest but statistically significant reduction of pain severity in the first four postoperative hours measured by the visual analogue scale (mean difference, -0.84; 95% CI, -1.10 to -0.59). However, a more recent meta-analysis found that only limited clinical data and biological plausibility support lidocaine infusions for the prevention of postoperative persistent pain (odds ratio, 0.29; 95% CI, 0.18 to 0.48). This study was designed to investigate whether lidocaine infusion after video-assisted thoracoscopic surgery (VATS) would lower PPS at postoperative 3 and 6 month.

Enrollment: 72 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled to undergo a muscle-sparing lateral minithoracotomy for different thoracic diseases

Exclusion criteria

• (1)ASA classification status III or above
• (2)Body weight<35kg
• (3)Liver cirrhosis
• (4)A history of previous thoracotomy
• (5)Pregnancy
• (6)Severe arrhythmia
• (7)Congestive heart failure
• (8)Opioid or steroid use 6 months before surgery
• (9)Allergy to lidocaine
• (10)Chronic pain syndrome (any type)
• (11)Emergency surgery
• (12)Incapacity to give an informed consent, Visual dysfunction or severe mental disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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72 participants in 2 patient groups, including a placebo group

Lidocaine

Experimental group

Description:

Lidocaine treatment

Treatment:

Drug: Lidocaine

Control

Placebo Comparator group

Description:

Placebo treatment

Treatment:

Drug: Control