Lidocaine Reduces Muscle Tremor is Beneficial for Intraoperative Recurrent Laryngeal Nerve Monitoring

B

Bo Wang,MD

Status

Unknown

Conditions

Thyroid Cancer
Accessory Nerve Injuries
Neck Cancer
Recurrent Laryngeal Nerve Injuries
EMG: Repetitive Nerve Stimulation Abnormality

Treatments

Drug: Lidocaine

Study type

Interventional

Funder types

Other

Identifiers

NCT03530033
BND IONM Lidocaine

Details and patient eligibility

About

In recent years, the application of intraoperative recurrent laryngeal nerve monitoring in thyroid surgery has greatly reduced the complications of recurrent laryngeal nerve injury. The use of intraoperative neurological monitoring requires the reduction of the dose of neuromuscular blockade, which often leads to muscle tremors during the application of electrical energy, which affects the fine separation around the muscles. This study explored the effect of local application of lidocaine on reducing muscle tremor during surgery and its optimal dose.

Full description

According to the random number method, eligible patients were randomly divided into 2 groups. Group A was the conventional surgery group, and Group B was the lidocaine group. The operative time for the separation of the sternocleidomastoid muscle from the two groups of patients was analyzed, as well as the length of time for the search for the accessory nerve and the effect of intraoperative nerve monitoring on the EMG signal.

Enrollment

40 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Thyroid papillary carcinoma
  • Lateral cervical lymph node metastasis
  • The diameter of the metastatic lymph nodes is less than 3cm
  • Without internal jugular vein invasion

Exclusion criteria

  • Lidocaine allergy sufferers

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

40 participants in 2 patient groups

Conventional surgery group
No Intervention group
Description:
Induction of anesthesia according to conventional neuromuscular blockade dose, no neuromuscular blockade drug maintenance during lateral neck dissection.
Lidocaine group
Experimental group
Description:
Anesthesia induction was performed according to conventional nerve monitoring neuromuscular blockade doses and lateral neck dissection was performed. When local muscle tremors occur, lidocaine is injected locally to eliminate muscle tremors.
Treatment:
Drug: Lidocaine

Trial contacts and locations

1

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Central trial contact

bo wang, md

Data sourced from clinicaltrials.gov

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