Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs

Florida Atlantic University

Status and phase: Enrolling; Phase 3

Conditions: Laceration of Skin

Treatments: Drug: Diphenhydramine; Drug: Lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT06910241

2195722

Details and patient eligibility

About

Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Lacerations requiring one layer of sutures
• Lacerations appropriate for repair by emergency physicians

Exclusion criteria

• Active bleeding from laceration
• Complex lacerations requiring multiple layers
• Lacerations to be repaired by a specialist service
• Patients with allergies to either diphenhydramine or lidocaine
• Laceration repairs would benefit from the use of epinephrine as an additive to the local anesthetic

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

Lidocaine

Active Comparator group

Treatment:

Drug: Lidocaine

Diphenhydramine

Experimental group

Treatment:

Drug: Diphenhydramine