LIdocaine veRsus Sufentanil Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass (LISRACC)

University Hospital Center (CHU) Dijon Bourgogne

Status: Completed

Conditions: Opioid Anaesthesia; Opioid Free Anaesthesia

Treatments: Other: Data collection

Study type: Observational

Funder types: Other

Identifiers

NCT05136794

GUINOT 2021-4

Details and patient eligibility

About

Since the 90's the concept of morphine sparing and morphine free anaesthesia (OFA) has progressively developed in non-cardiac surgery. The principle is based on the fact that in a sleeping patient a sympathetic reaction marked by hemodynamic modifications does not translate into a painful phenomenon, that a painful phenomenon in a sleeping patient is not memorized, that hormonal stress, the sympathetic reaction and the inflammatory reaction can be controlled by other therapeutic classes than a morphine agent. This therapeutic management would avoid the side effects associated with the use of morphine. In this hypothesis, OFA is more and more practiced in various situations without the real impact in terms of clinical benefit being clearly demonstrated. In cardiac surgery, some centers practice OFA with various protocols.The purpose of this work is to retrospectively evaluate over a defined period the incidence of postoperative complications, length of stay in the ICU/hospital, and death rate between patients managed with/without OFA based on lidocaine.

Enrollment: 1,772 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

age over 18 years Cardiac surgery with cardiopulmonary bypass performed between January 2019 and June 2021

Exclusion criteria

LVAD Heart transplantation Incomplete data in relation to outcomes

Trial design

1,772 participants in 2 patient groups

Opioid free anaesthesia

Description:

patient anesthtesized with lidocaine

Treatment:

Other: Data collection

Opioid anaesthesia

Description:

patients anesthetized with sufentanil

Treatment:

Other: Data collection