Lifestyle Interventions for Seniors With Apnea

Johns Hopkins University

Status: Completed

Conditions: Obstructive Sleep Apnea

Treatments: Behavioral: Lifestyle Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01422863

LIZA

Details and patient eligibility

About

The overall goal of this study is to determine the efficacy of a lifestyle intervention, consisting of a weight loss diet and exercise on sleep apnea in older adults. The investigators will conduct a 3-month intervention in men and women who are sedentary with suspected sleep apnea. The investigators hypothesize that the intervention will lead to marked improvements in sleep apnea severity and cardiovascular risk markers.

Full description

Frailty, a condition characterized by a decrease in physiological reserve and increased risk for adverse health-related outcomes, is an increased risk of aging, especially in the presence of co-morbid conditions. Sleep apnea is also highly prevalent with increasing age. Both conditions share common pathologies, suggesting that sleep apnea may increase the risk of developing or exacerbate the consequences of frailty. Lifestyle interventions as strategies for treating sleep apnea and associated co-morbidities, thereby highlighting a feasible approach by which to reduce the incidence or progression of frailty. The specific aims of this study are to: 1) determine the effectiveness of a lifestyle intervention (LI), consisting of a weight loss diet and supervised exercise, on reducing sleep apnea in older adults, and 2) determine whether this intervention is effective at improving parameters that are common to both sleep apnea and frailty, such as poor physical functional capacity and body composition, impaired or abnormal cardiometabolic function and increased levels of inflammation.

Enrollment: 18 patients

Sex: All

Ages: 60 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged 60-75
• BMI between 30-42
• Apnea-Hypopnea Index above 10 events per hour (verified at baseline testing)

Exclusion criteria

• currently following a weight loss diet
• history of substance abuse
• participating in moderate to vigorous activity most days of the week
• history of cardiovascular disease
• currently being treated for sleep apnea
• current cigarette smoking

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 1 patient group

Lifestyle Intervention

Experimental group

Treatment:

Behavioral: Lifestyle Intervention