Lifestyle Modification in Psoriatic Patients With Fatty Liver

Cairo University (CU)

Status: Unknown

Conditions: Fatty Liver; Psoriasis

Treatments: Other: usual lifestyle; Other: lifestyle modification

Study type: Interventional

Funder types: Other

Identifiers

NCT05125757

P.T.REC/012/003344

Details and patient eligibility

About

Several recent reports have shown an increased prevalence of nonalcoholic fatty liver disease (NAFLD) in those with psoriasis, which may reflect the increased occurrence of metabolic syndrome in this patient population.

Full description

the recruitment of 60 fatty live men with chronic disease, psoriasis, will be classified to lifestyle modification group (foe 12 weeks, this patients will take supervised energy or diet restriction program plus their usual immunosuppressive drugs ) and control group will continue their drug program only)

Enrollment: 60 estimated patients

Sex: Male

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• psoriasis obese patients with coexisting fatty liver
• chronic plaque psoriasis
• patients who will not show any change in immuno-modulating psoriasis therapies for at least five months before participation in the study.

Exclusion criteria

• no metabolic syndrome
• no renal or cardiac or pulmonary disorders
• other types of psoriasis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

intervention group

Experimental group

Description:

The patients of this group will receive their usual immuno-modulating therapy plus life style modification (energy or diet restriction in addition to daily walking, 15000 steps)

Treatment:

Other: lifestyle modification

control group

Active Comparator group

Description:

The participants of this group will receive their usual immuno-modulating therapy and continuing their usual diet and activities

Treatment:

Other: usual lifestyle