LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)

Gustave Roussy

Status and phase: Completed; Phase 3

Conditions: Li Fraumeni Syndrome

Treatments: Other: whole body MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT01464086

CSET2011/1748

Details and patient eligibility

About

The purpose of this study is to compare the diagnostic efficacy of two follow-up schedules for the early detection of cancers in the population under study on cancer incidence at 3 years.

Enrollment: 107 patients

Sex: All

Ages: 5 to 71 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• P53 mutation

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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107 participants in 2 patient groups

Standard arm

No Intervention group

Description:

standard follow-up

Intensive follow-up

Experimental group

Description:

Standard follow-up plus whole body MRI at inclusion, one and two years

Treatment:

Other: whole body MRI