LIght Sedation Pressure Support (LIPS)

University Hospital, Lille

Status: Withdrawn

Conditions: ARDS, Human

Treatments: Other: decrease of sedation doses and switch of ventilator settings

Study type: Interventional

Funder types: Other

Identifiers

NCT03783468

2017_18

2018-A01036-49 (Other Identifier)

Details and patient eligibility

About

Sedation may have many drawbacks in ICU patients: cardiovascular, neurologic, muscular.

Light sedation and Pressure Support ventilation is feasible in ARDS patients. However spontaneous breathing can lead to high transpulmonary pressure.

The goal of the study is to measure transpulmonary pressure before sedation decrease and after stabilization. The main endpoint is transpulmonary pressure less than 24 cmH2O.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ARDS (Berlin definition)
• social insurance

Exclusion criteria

• neuromuscular disorders
• pregnancy
• need for muscular paralysis
• need for deep neurosedation
• more than 24hrs of artificial ventilation
• cystic fibrosis

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

light sedation pressure support ventilation

Experimental group

Treatment:

Other: decrease of sedation doses and switch of ventilator settings