Link Between Plasma Citrulline and Lipopolysaccharide Concentrations in the Critically Ill (CITRANS)

Centre Hospitalier Universitaire de Besancon

Status: Unknown

Conditions: Critically Ill

Treatments: Other: additional blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT02902276

P/2016/187

Details and patient eligibility

About

In critically ill patients, the small bowel permeability is increased, leading to bacterial translocation, and systemic inflammatory response syndrome.

Plasma citrulline is a validated biomarker of functional enterocyte mass. Lipopolysaccharide (LPS) is a part of Gram negative bacteria, and plasma LPS concentration is a biomarker of bacterial translocation. The link between plasma citrulline and LPS in the critically ill is unknown. Investigators hypothesize that patients presenting with low plasma citrulline concentration, with presumed altered small bowel function, would have an increased phenomenon of bacterial translocation, and increased plasma LPS concentration. Investigators aimed to evaluate the link between plasma citrulline and LPS concentrations in critically ill patients at the time of ICU admission.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Critically ill patients requiring ICU admission for at least 48 hours
• Adults

Exclusion criteria

• Chronic small bowel disease
• Chronic renal failure (clearance of creatinine < 50 mL/min)
• Pregnancy