Linkage Study of Long QT Syndrome In An Amish Kindred

National Institutes of Health (NIH)

Status: Completed

Conditions: Long QT Syndrome; Ventricular Fibrillation; Cardiovascular Diseases; Tachycardia, Ventricular; Heart Diseases

Study type: Observational

Funder types: NIH

Identifiers

NCT00005250

R01HL041035 (U.S. NIH Grant/Contract)

1132

Details and patient eligibility

About

To screen by electrocardiography the entire population of 1,400 individuals in seven Amish Mennonite communities in order to perform genetic linkage studies of long QT syndrome (LQTS).

Full description

BACKGROUND:

LQTS is a severe heart disorder leading to sudden death due to ventricular tachycardia or ventricular fibrillation. The syndrome segregated as a Mendelian recessive in the highly inbred population under study and resulted in the sudden death of several members of the population.

DESIGN NARRATIVE:

The entire population was screened to identify cases of LQTS. In addition, 29 obligate heterozygotes were studied by 24-hour Holter monitoring to determine whether these gene carriers had any subtle phenotypes. The data were subjected to complex segregation and linkage analysis to establish the mode of inheritance and penetrance of LQTS.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Sex: Male

Ages: Under 100 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

No eligibility criteria