Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia (MOTOLANG-AVC)
Status
Enrolling
Conditions
Stroke
Aphasia
Treatments
Other: Motor training with a tool
Other: Motor training with a hand
Other: Syntactic comprehension battery (BCS)
Other: Montreal Cognitive Assessment (MOCA)
Other: on/off effect of tool motor training
Other: The Box and Block Test (BBT)
Other: linguistic tasks
Other: Purdue Pegboard Test
Study type
Interventional
Funder types
Other
Identifiers
Details and patient eligibility
About
Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other.
The aim of this study is to show that a motor training with a tool (pliers) can improve short-term and long-term language abilities of aphasic patients who had a stroke at least 3 months ago.
The investigators hypothesis is that there is a learning transfer between tool use and language abilities in aphasic patients with an inferior frontal gyrus (IFG) lesion caused by a stroke, thanks to their shared neural resources.
Investigators aim to study long and short-time effects of this tool motor training with three experiments:
- E1 will study short-term effects by estimating pre-post effect of a motor training on language abilities. Investigators will experiment different effectors: tool, hand, none (control group); on patients and healthy volunteers.
- E2 will study long-term effects with multiple single-case experimental designs (SCED). Patients will undergo four weeks of on-off design.
- E3 will study long-term effects by estimating the efficiency of an experimental sensorimotor protocol of four weeks, comparing a group of patients with the experimental sensorimotor protocol to a control group of patients
Enrollment
360 estimated patients
Sex
All
Ages
18+ years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
For all participants:
- Adult male or female aged 18 years and over
- Right-handed
- Having signed an informed and written consent
- Affiliated to a social security scheme
- Have French as their first language
For patients :
- Left inferior frontal gyrus lesion following a stroke
- Stroke more than 3 months old
- Aphasia proven by a pathological score on the A-2 test of the Syntax Comprehension Battery (BCS)
Exclusion criteria
For all participants:
- Cognitive abilities that prevent completion of the study tasks (assessed with the MOntreal Cognitive Assesment (MOCA))
- Language skills impaired by other disorders (for example neurodegenerative disease)
- Cognitive impairing treatments (for example psychotropic drugs)
- Neurovisual disorder (hemineglect, unilateral spatial neglect)
- Impairment of both upper limb abilities that prevent motor training (pathological score in the Purdue Pegboard Test and/or Box and Block Test).
- Recurrence of a stroke impacting the reorganisation of neural networks
- Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship)
- Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant
- Participation in another study at the same time as this one
Trial design
Primary purpose
Basic Science
Allocation
Randomized
Interventional model
Parallel Assignment
Masking
None (Open label)
360 participants in 9 patient groups
Sub-study E1, arm 1, patients and tool motor training
Experimental group
Description:
patients undergo a 30 minutes tool motor training and two linguistic tasks (one before and one after).
Treatment:
Other: linguistic tasks
Other: The Box and Block Test (BBT)
Other: Purdue Pegboard Test
Other: Syntactic comprehension battery (BCS)
Other: Montreal Cognitive Assessment (MOCA)
Other: Motor training with a tool
Sub-study E1, arm 2, patients and hand motor training
Experimental group
Description:
patients undergo a 30 minutes hand motor training and two linguistic tasks (one before and one after).
Treatment:
Other: linguistic tasks
Other: The Box and Block Test (BBT)
Other: Purdue Pegboard Test
Other: Syntactic comprehension battery (BCS)
Other: Motor training with a hand
Other: Montreal Cognitive Assessment (MOCA)
Sub-study E1, arm 3, patients and no motor training (control group)
Experimental group
Description:
patients only undergo two linguistic tasks separated by a 30-minutes break (without motor activity (control group)).
Treatment:
Other: linguistic tasks
Other: The Box and Block Test (BBT)
Other: Purdue Pegboard Test
Other: Syntactic comprehension battery (BCS)
Other: Montreal Cognitive Assessment (MOCA)
Sub-study E1, arm 4, healthy volunteers and tool motor training
Experimental group
Description:
healthy volunteers undergo a 30 minutes tool motor training and two linguistic tasks (one before and one after).
Treatment:
Other: linguistic tasks
Other: The Box and Block Test (BBT)
Other: Purdue Pegboard Test
Other: Syntactic comprehension battery (BCS)
Other: Montreal Cognitive Assessment (MOCA)
Other: Motor training with a tool
Sub-study E1, arm 5, healthy volunteers and hand motor training
Experimental group
Description:
healthy volunteers undergo a 30 minutes hand motor training and two linguistic tasks (one before and one after).
Treatment:
Other: linguistic tasks
Other: The Box and Block Test (BBT)
Other: Purdue Pegboard Test
Other: Syntactic comprehension battery (BCS)
Other: Motor training with a hand
Other: Montreal Cognitive Assessment (MOCA)
Sub-study E1, arm 6, healthy volunteers and no motor training (control group)
Experimental group
Description:
healthy volunteers only undergo two linguistic tasks separated by a 30-minutes break (without motor activity (control group)).
Treatment:
Other: linguistic tasks
Other: The Box and Block Test (BBT)
Other: Purdue Pegboard Test
Other: Syntactic comprehension battery (BCS)
Other: Montreal Cognitive Assessment (MOCA)
Sub-study E2, arm 1, single case design
Experimental group
Description:
patients undergo 4 weeks of tool motor training according to an on/off design.
Treatment:
Other: linguistic tasks
Other: The Box and Block Test (BBT)
Other: Purdue Pegboard Test
Other: on/off effect of tool motor training
Other: Syntactic comprehension battery (BCS)
Other: Montreal Cognitive Assessment (MOCA)
Sub-study E3, arm 1, patients and 4 week experimental sensorimotor protocol
Experimental group
Description:
patients undergo 4 weeks of tool motor training
Treatment:
Other: linguistic tasks
Other: The Box and Block Test (BBT)
Other: Purdue Pegboard Test
Other: Syntactic comprehension battery (BCS)
Other: Montreal Cognitive Assessment (MOCA)
Other: Motor training with a tool
Sub-study E3, arm 2, control group of patients
Experimental group
Description:
aphasic patients receiving the standard treatment as a control group
Treatment:
Other: linguistic tasks
Other: The Box and Block Test (BBT)
Other: Purdue Pegboard Test
Other: Syntactic comprehension battery (BCS)
Other: Montreal Cognitive Assessment (MOCA)
Trial contacts and locations
3
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Central trial contact
Claudio BROZZOLI; Mallory AUGIER
Data sourced from clinicaltrials.gov
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