Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia (TOCAS)

Hôpital le Vinatier

Status: Terminated

Conditions: Schizophrenia

Treatments: Other: Performances of patients and controls on temporal task

Study type: Interventional

Funder types: Other

Identifiers

NCT03432000

2017-A03019-44

Details and patient eligibility

About

People with schizophrenia show disturbances in the perception of time. Among these alterations are the perturbations of the temporal order judgment. They are characterized by the fact that, as opposed to the general population, people with schizophrenia require a longer time interval between two successive stimuli to estimate which of the two events appeared first. If these alterations are now well documented, their consequences remain little explored. Among these consequences could however appear distortions of the judgment of causality (likely to underlie certain delusional interpretations) as well as a distressing experience of loss of the continuity of the lived experience (that could contribute to the alterations basic of self-awareness).

Full description

The objective of our work lies in the study of the links between temporal sequencing, subjective perception of time and causality.

To carry out this work, the investigators will rely on an experimental paradigm (derived from Michotte's paradigm) which makes it possible to explore the links between temporal sequencing and perception of causality, validated in the normal subject. subjective consequences of these alterations will be explored using a phenomenological-inspired clinical scale (EAWE time-scale items)

Enrollment: 52 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Subjects with schizophrenia:

• Age from 18 to 45 years
• Diagnosis of schizophrenia according to DSM V criteria
• French mother tongue
• Psychotropic treatment unchanged during the month preceding the inclusion
• Stable symptomatology
• Normal or corrected visual acuity (> 0.8 at Snellen scale) and normal color vision
• Patients who gave informed consent to participate in the study

Control subjects (healthy volunteers):

• Age from 18 to 45 years
• Absence of neurological and psychiatric disorders
• French mother tongue

Exclusion criteria

• Recent addiction and abuse of cannabis or any other substance (according to DSM V criteria)
• Neurological disorders of vascular, infectious or neurodegenerative origin
• Taking somatic drugs with a cerebral or mental impact (eg corticosteroids)
• Disabling sensory disturbances, and in particular visual acuity
• Participation in a Neuro Cognitive Remediation Program
• Schizophrenia resistant to neuroleptic treatments
• Persons protected by law (pregnant women, minors, major under guardianship ...)

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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52 participants in 2 patient groups

subjects with schizophrenia

Experimental group

Description:

Performances on temporal task Subjective alterations of time perception in patients with an adapted scale (EAWE) Global symptomatology with PANSS (positive and negative symptom scale)

Treatment:

Other: Performances of patients and controls on temporal task

healthy subjects

Sham Comparator group

Description:

Evaluate the links (correlation) between perception of temporal sequencing and perception of causality using an adapted experimental paradigm (Michotte paradigm) and to compare performance between healthy subjects and controls Investigate the existence of a correlation between these alterations and the peculiarities of the subjective experience of time (EAWE scale) in the group of subjects with schizophrenia

Treatment:

Other: Performances of patients and controls on temporal task