Lipid Layer Thickness Pre and Post Lid Scrubs With Cliradex (HONDA)

University of Waterloo

Status: Completed

Conditions: Dry Eye

Treatments: Other: Cliradex

Study type: Interventional

Funder types: Other

Identifiers

NCT02493244

20714

Details and patient eligibility

About

Tears play a vital role in vision. A thin layer of tears is always present to cover the surface of the eye for optimal comfort and vision. There are several layers to the tear film, and the outer most layer is comprised of lipids. This lipid layer prevents evaporation of the tears and may be disrupted in people suffering from symptoms of dry eye. Cleaning eyelids with Cliradex wipes have shown to be effective in reducing dry eye symptoms in some patients, and the purpose of this study is to evaluate the tear film lipid layer thickness before and after one months treatment with Cliradex Wipes.

Enrollment: 20 patients

Sex: All

Ages: 17+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Is at least 17 years of age and has full legal capacity to volunteer;
2. Has read and signed an information consent letter;
3. Is willing and able to follow instructions and maintain the appointment schedule;
4. Have not worn contact lenses in the past month;
5. Has symptomatic dry eye with SPEED questionnaire score ≥6;
6. Corneal staining grade ≥2 on the Oxford scale.

Exclusion criteria

1. Has any known active ocular disease and/or infection;
2. Has a systemic condition that in the opinion of the investigator may affect a study outcome variable;
3. Is using any systemic or topical medications that in the opinion of the investigator may affect a study outcome variable;
4. Have used rewetting drops for a period of 2 days prior to screening visit;
5. Has known sensitivity to the diagnostic pharmaceuticals to be used in the study;
6. Is pregnant, lactating or planning a pregnancy at the time of enrolment by verbal confirmation at the screening visit;
7. Is aphakic;
8. Has undergone refractive error surgery;
9. Has taken part in another (pharmaceutical) research study within the last 30 days.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Treatment

Experimental group

Description:

Participants clean their eyelids with Cliradex wipes before going to bed at night.

Treatment:

Other: Cliradex

Control

No Intervention group

Description:

No treatment