Lipid Metabolism in COVID-19 Severe Pneumonia Compared With Severe Pneumonia Caused by Other Pathogen (COVIDOLIP)

University Hospital Center (CHU) Dijon Bourgogne

Status: Completed

Conditions: COVID-19 Severe Pneumonia; Severe Pneumonia Due to Other Pathogene

Treatments: Biological: biological assays in particular on the lipid metabolism

Study type: Observational

Funder types: Other

Identifiers

NCT04435223

NGUYEN AOIc 2020

Details and patient eligibility

About

SARS-COV 2 infection might be responsible for sever pneumonia. Obesity seems to be a risk factor for severe SARS-COV 2 pneumonia. Lipid metabolism alteration are described with both obesity and sepsis. The aim of the present study was to describe association between lipid metabolism, obesity, sepsis inflammation and clinical outcome in COVID-19 patient with severe pneumonia compared with severe pneumonia caused by other pathogenes.

Enrollment: 62 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 2 of the following criteria: Cough/ Dyspnea/ Spitting/ Thoracic pain/ Hyperthermia (>=38 °C) Hypothermia (< 35°C) AND new radiologic pulmonary infiltrate
• At admission or within 48 hours following hospital admission
• With 2 qSOFA criteria: MAP =< 100 mmHg, Respiratory Rate >= 22, Glasgow score < 15 OR on mechanical ventilation OR under vasopressor
• Age > 18
• affiliated to social security

Exclusion criteria

• Pregnancy
• immunodepression
• Pathology known to cause severe lymphopenia
• hospitalisation within 3 month before inclusion AND sepsis

Trial design

62 participants in 2 patient groups

COVID-19 severe pneumonia

Treatment:

Biological: biological assays in particular on the lipid metabolism

Severe pneumonia due to other pathogene

Treatment:

Biological: biological assays in particular on the lipid metabolism