Lipidome and Microbiome Profile of Acne

University of California (UC) Davis

Status and phase

Active, not recruiting

Phase 2

Phase 1

Conditions

Acne Vulgaris

Treatments

Drug: Doxycycline

Study type

Interventional

Funder types

Other

Identifiers

NCT02713607

867744

Details and patient eligibility

About

Lipidome and microbiome analysis in subjects with acne on doxycycline. Investigators will look at the skin lipidome, blood lipidome, gut micro biome and skin micro biome.

Investigators will look at the changes between acne subjects and control participants, but also the changes that occur after the use of antibiotics and how this is altered.

Full description

We will look at acne subjects, and controls.

We will look at four things

skin lipidome
skin microbiome
gut microbiome
blood lipidome

Investigators will assess this in acne participants before and after doxycycline and compare them to controls.

Enrollment

30 patients

Sex

All

Ages

15+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Aged 15 and older
Subjects/parents/legal guardian is able to read and comprehend study procedure and consent forms.
Have already been prescribed Doxycycline by their physician for acne or to be eligible to be prescribed Doxycycline for acne
Have acne that is diagnosed by a board certified dermatologist.

Exclusion criteria

Those who have received systemic antibiotics within four weeks of starting the study.
Those who have received systemic isotretinoin within six weeks of starting the study.
Those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome
Those who are pregnant, prisoners or cognitively impaired.
Those subjects who are currently using proton pump inhibits (as studies have shown this may impact the gut microbiome) (4)
Those who have a BMI greater than >30 kg/m2, as studies have shown a reduction in the variability of intestinal microbes within this population (5).
Those who have initiated or changed brand of oral contraceptive pill within 4 weeks of starting the study.
Those who have autoimmune disorders as this group has been shown to have an altered microbiome (6)
Those who have diabetes (6), immunodeficiencies (7), inflammatory bowel disease (6), hypercholesterolemia, as these groups have been shown to have altered gut microbiomes
Those who have taken oral probiotic supplements (8) within 4 weeks of starting the study
Given the nature of the instructions that need to be adhered to for accurate collection of samples and this data, non-English speaking individuals will be excluded from this pilot study.
Allergies to the tetracycline group of antibiotics
Those who do not fit the inclusion criteria