Lipolytic Effects of GH in Human Subjects in Vivo

University of Aarhus

Status: Completed

Conditions: Metabolic Diseases; Growth Hormone Treatment

Treatments: Drug: Pegisomant; Drug: Growth Hormone

Study type: Interventional

Funder types: Other

Identifiers

NCT02782221

GH02

Details and patient eligibility

About

Growth hormone (GH) induces fat metabolism. The mechanisms underlying the fat metabolizing effects of GH remain elusive. However, it is known that insulin suppresses fat metabolism, and GH inhibits the expression of certain insulin-dependent signaling proteins. We therefore hypothesize that the fat metabolizing effects of GH depend on abrogation of insulin-dependent signaling pathways.

In order to investigate the fat metabolizing effects of GH, we'll analyze consecutive adipose tissue biopsies taken after GH exposure and GH blocking, respectively.

Knowledge of the effects of growth hormone and fat metabolism can in shot-sight as well as in long-sight have great importance for the understanding of growth disorders from overweight and type 2 diabetes to malnutrition and eating disorders.

Enrollment: 9 patients

Sex: Male

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy males
• no medication
• BMI 28-35

Exclusion criteria

• known diseases
• regular medication

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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9 participants in 2 patient groups, including a placebo group

Growth hormone

Active Comparator group

Description:

Subjects are receiving growth hormone

Treatment:

Drug: Growth Hormone

Placebo

Placebo Comparator group

Description:

Subjects are receiving pegvisomant to block the action of growth hormone

Treatment:

Drug: Pegisomant