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Lipolytic Effects of GH in Human Subjects in Vivo

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University of Aarhus

Status

Completed

Conditions

Metabolic Diseases
Growth Hormone Treatment

Treatments

Drug: Pegisomant
Drug: Growth Hormone

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Growth hormone (GH) induces fat metabolism. The mechanisms underlying the fat metabolizing effects of GH remain elusive. However, it is known that insulin suppresses fat metabolism, and GH inhibits the expression of certain insulin-dependent signaling proteins. We therefore hypothesize that the fat metabolizing effects of GH depend on abrogation of insulin-dependent signaling pathways.

In order to investigate the fat metabolizing effects of GH, we'll analyze consecutive adipose tissue biopsies taken after GH exposure and GH blocking, respectively.

Knowledge of the effects of growth hormone and fat metabolism can in shot-sight as well as in long-sight have great importance for the understanding of growth disorders from overweight and type 2 diabetes to malnutrition and eating disorders.

Enrollment

9 patients

Sex

Male

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • healthy males
  • no medication
  • BMI 28-35

Exclusion criteria

  • known diseases
  • regular medication

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

9 participants in 2 patient groups, including a placebo group

Growth hormone
Active Comparator group
Description:
Subjects are receiving growth hormone
Treatment:
Drug: Growth Hormone
Placebo
Placebo Comparator group
Description:
Subjects are receiving pegvisomant to block the action of growth hormone
Treatment:
Drug: Pegisomant

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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