Lipoprotein Interactions and Platelet Function in Healthy Individuals and Those With Lipid Disorders

Lifespan

Status: Enrolling

Conditions: Lipid Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT06747000

2195890

710-7149062 (Other Grant/Funding Number)

Details and patient eligibility

About

This study looks at how lipoproteins, which are particles in the blood that transport cholesterol, influence heart and blood vessel health. Beyond just their levels, the way these particles function plays a key role in preventing or contributing to disease. In some conditions, like high cholesterol or diabetes, lipoproteins may not work properly, increasing the risk of clogged arteries and other complications.

The investigators aim to study these changes in people with lipid disorders to better understand their impact on blood health and to find new ways to prevent and treat heart disease.

Full description

Traditionally, lipoproteins have been associated with cardiovascular protection, but emerging research indicates that their functionality may be a more critical factor than their levels in evaluating cardiovascular risk. Lipoproteins, such as HDL, LDL, and VLDL, play vital roles in processes like reverse cholesterol transport and demonstrate anti-inflammatory, antioxidative, and antiplatelet properties. However, in conditions like atherosclerosis, diabetes, and dyslipidemia, these lipoproteins often become dysfunctional, and the mechanisms behind this dysfunction remain incompletely understood.

This study aims to thoroughly investigate the pathogenic roles of lipoproteins by examining their structural and functional modifications and their influence on platelet activity in individuals with lipid disorders.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 69 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Abnormalities in lipid panels
• Able to provide informed consent
• Between the age of 18 and 69

Exclusion criteria

• Drug or alcohol abuse within 6 months or significant mental/psychological impairment
• Current smokers
• Subjects with known bleeding disorders (for example, hemophilia)
• Subjects requiring regular transfusions for any reason
• No ethnic/racial groups will be excluded

Trial design

80 participants in 2 patient groups

Individuals with lipid disorders

Description:

Individuals with lipid disorders (elevated HDL and LDL)

Healthy individuals

Description:

Healthy individuals with normal lipid values and without lipid-related diseases