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This study plans to learn more about measuring Lipoprotein lipase (LPL) activity in humans. LPL is an enzyme in the breakdown of certain types of fats into smaller parts. Lipoprotein lipase deficiency (LPLD) is a very rare genetic disorder in which lipoprotein enzyme is no longer functional. This can cause conditions known as high triglycerides in the blood and inflammation of the pancreas.
Investigational medications to treat LPLD are currently being developed. In order to see if these medications are effective, it is necessary to be able to accurately measure LPL activity in humans.
LPL activity has been successfully measured in animal models after giving heparin. Heparin is a blood thinner which is approved by the FDA. It is originally used to prevent blood clots. This study will administer heparin to healthy adults through intravenous infusion (IV). Blood samples will be collected before and after the infusion to test LDL levels.
The purpose of this study is to develop a cheap, more reliable standard for assessment of LPLD in patients
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Exclusion criteria
Past history of LPL deficiency
Hypercholesterolemia (Cholesterol >200, LDL >160, HDL <35) hypertriglyceridemia (TG>150), any familial lipid disorder
Diabetes mellitus (type 1 or 2)
Uncontrolled hypertension SBP>140, DBP>90
History of hemorrhagic stroke
Current pregnancy
History of major surgery, invasive procedure or trauma within the last 30 days, or planned major surgery within 30 days after participating in the study
Exposure to heparin (unfractionated heparin or low molecular weight heparin) within 30 days prior to screening
History of allergy to heparin
History of heparin-induced thrombocytopenia
Current smoking
Active ulcerative or angiodysplastic GI diseases
Thrombocytopenia or platelet disorders (Platelet count <100,000/UL)
Major health issues which may affect the safety of study subject, including but not limited to:
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Data sourced from clinicaltrials.gov
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