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Liquorice and Salivary Cortisol

U

Umeå University

Status

Unknown

Conditions

Cushing Syndrome
Hypercortisolism

Treatments

Dietary Supplement: Liqourice

Study type

Interventional

Funder types

Other

Identifiers

NCT04045015
Liquorice_Saliva_01

Details and patient eligibility

About

Salivary cortisol is used as a diagnostic analysis in the investigation of suspected Cushings' syndrome. This study evaluates if liqourice intake increases salivary cortisol in healthy individuals. Late night salivary cortisol and cortisone is analysed before, during and after 7 days of liqourice intake in three different doses.

Enrollment

30 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Men and women 18-65 years.

Exclusion criteria

  • Known pituitary or adrenal disease
  • Medication with glucocorticoids (incl. inhalation, nasal, dermal)
  • Known hypertension or blood pressure >140/90 at screening
  • tobacco use
  • Subjective problems in oral mucosa or saliva
  • Abnormal diurnal rhythm (awake 03:00 - 05:30)
  • Difficulties taking liqourice for 3 weeks or refraining from liqourice during 4 weeks

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

30 participants in 3 patient groups

glycyrrhizic acid 1.5 mg/kg body weight
Active Comparator group
Description:
Liqourice corresponding to 1.5 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.
Treatment:
Dietary Supplement: Liqourice
glycyrrhizic acid 3.0 mg/kg body weight
Active Comparator group
Description:
Liqourice corresponding to 3.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.
Treatment:
Dietary Supplement: Liqourice
glycyrrhizic acid 6.0 mg/kg body weight
Active Comparator group
Description:
Liqourice corresponding to 6.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.
Treatment:
Dietary Supplement: Liqourice

Trial contacts and locations

1

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Central trial contact

Per Dahlqvist, MD, PhD; Nils Bäcklund, MD

Data sourced from clinicaltrials.gov

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