Liquorice and Salivary Cortisol

Umeå University

Status: Unknown

Conditions: Cushing Syndrome; Hypercortisolism

Treatments: Dietary Supplement: Liqourice

Study type: Interventional

Funder types: Other

Identifiers

NCT04045015

Liquorice_Saliva_01

Details and patient eligibility

About

Salivary cortisol is used as a diagnostic analysis in the investigation of suspected Cushings' syndrome. This study evaluates if liqourice intake increases salivary cortisol in healthy individuals. Late night salivary cortisol and cortisone is analysed before, during and after 7 days of liqourice intake in three different doses.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men and women 18-65 years.

Exclusion criteria

• Known pituitary or adrenal disease
• Medication with glucocorticoids (incl. inhalation, nasal, dermal)
• Known hypertension or blood pressure >140/90 at screening
• tobacco use
• Subjective problems in oral mucosa or saliva
• Abnormal diurnal rhythm (awake 03:00 - 05:30)
• Difficulties taking liqourice for 3 weeks or refraining from liqourice during 4 weeks

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 3 patient groups

glycyrrhizic acid 1.5 mg/kg body weight

Active Comparator group

Description:

Liqourice corresponding to 1.5 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.

Treatment:

Dietary Supplement: Liqourice

glycyrrhizic acid 3.0 mg/kg body weight

Active Comparator group

Description:

Liqourice corresponding to 3.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.

Treatment:

Dietary Supplement: Liqourice

glycyrrhizic acid 6.0 mg/kg body weight

Active Comparator group

Description:

Liqourice corresponding to 6.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.

Treatment:

Dietary Supplement: Liqourice