Liraglutide Efficacy and Action in Non-Alcoholic Steatohepatitis (LEAN)

University of Birmingham

Status and phase

Completed

Phase 2

Conditions

Nonalcoholic Steatohepatitis

Treatments

Other: Liraglutide-placebo

Drug: Liraglutide

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01237119

ISRCTN85774727 (Registry Identifier)

HE2013

Details and patient eligibility

About

The purpose of this study is to investigate whether 48 weeks treatment with once-daily injections of liraglutide improves liver disease (liver fat, inflammation and scarring) and related metabolic parameters in overweight patients with nonalcoholic steatohepatitis, enough to warrant further investigation.

Full description

Non-alcoholic fatty liver disease (NAFLD) is responsible for an increasing prevalence of liver disease and is becoming the commonest cause of liver disease in the western world. NAFLD is recognised to be the hepatic manifestation of the metabolic syndrome, which is a cluster of metabolic abnormalities characterised by abdominal obesity, insulin resistance, impaired glucose metabolism, hypertension and dyslipidaemia. In its mildest form there is an accumulation of fat in the liver (steatosis) without any liver damage, however in many cases it progresses to non-alcoholic steatohepatitis (NASH), and cirrhosis.

Current treatment options for NASH are limited in efficacy, necessitating the development of more effective options. New agents such as Glucagon-like Peptide-1 (GLP-1) agonists that improve diabetic control and facilitate weight loss have been suggested as therapies in NASH.

No published studies to date have assessed the impact of the GLP-1 agonist, Liraglutide, on liver histology and metabolism in obese patients with NASH. This study hypothesises that treatment with liraglutide will result in a significant improvement in histological disease activity in overweight patients with NASH, in the presence or absence of Type 2 Diabetes (T2DM)

Enrollment

52 patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

NASH on liver biopsy (within 6 months of screening visit).
NAFLD Activity Score (NAS) ≥ 3, comprising of a minimum of 1 point from each of the individual steatosis, lobular inflammation and hepatocyte ballooning scores
Body Mass Index (BMI) ≥ 25 at randomisation
Type 2 Diabetes Mellitus/impaired glucose tolerance or normal glucose tolerance

Exclusion Criteria (brief):

Insulin dependent diabetes
Glycosylated Haemoglobin (HbA1c) > 9.0%
treatment with dipeptidyl peptidase 4 (DPP-IV) inhibitors, Glucagon-like Peptides (GLP) 1 analogues, thiazolidinediones (TZDs)
Past Medical History of Acute (or chronic) pancreatitis/pancreatic carcinoma, weight loss surgery, liver transplantation, Medullary thyroid cancer, hepatocellular carcinoma (HCC), Multiple Endocrine Neoplasia (MEN) syndrome, malignancy (within last 3 years, exception of treated skin malignancy)
Other liver aetiologies (i.e. drug-induced, viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, haemochromatosis, alpha 1 anti-trypsin deficiency, Wilsons disease)
concomitant or recent use of orlistat, prednisolone,
Refusal or lacks capacity to give informed consent to participate in the trial
Participation in any clinical trial of an investigational therapy or agent within 3 months of randomisation
Patient (or carer) deemed not competent at using the correct site and technique for subcutaneous injection of the trial treatment (containing dummy drug on practice) at visit 2
NAS<3
Child's B or C cirrhosis
Abnormal clinical examination of thyroid (i.e. unexplained goitre or palpable nodules)
Liver enzymes > 10 x upper limit of normal
Average alcohol consumption per week > 21 units (210g) male, >14 units (140g) female within the last 5 years.
>5% weight loss since the diagnostic liver biopsy was obtained.
Recent or concomitant use of steroids (oral), methotrexate, amiodarone, Orlistat
Addition or significant change (as judged by the chief investigator) in dose of the following drugs; Angiotensin converting enzymes (ACE)-inhibitors, Angiotensin receptor blockers (ARBs) and/or Multi-vitamins (containing Vitamin E)
Known positivity for antibody to Human Immunodeficiency virus (HIV)
Serum creatinine > 150 μmol/L or currently being treated with renal replacement therapy
Past medical history of multiple drug allergies (defined as anaphylactoid drug reactions in >2 drug groups)
Presence of any acute/chronic infections or illness that at the discretion of the chief investigator might compromise the patient's health and safety in the trial
Pregnancy or breastfeeding
Women, of child-bearing age, who are not willing to practise effective contraception (i.e. barrier, oral contraceptive pill, implanon or history hysterectomy) for the 48 week duration of the trial and for one-month after the last administration of the drug.
Men, sexually active with women of child-bearing age, who are not willing to practise effective contraception for the 48 week duration of the trial and for one-month after the last administration of the drug.