Lithothamnion Species on Blood Lactate During Exhaustive Exercise in Trained Cyclists (AAPt)

University College Dublin

Status: Unknown

Conditions: Lactate Blood Increase; Exercise-Induced Lactic Acidemia

Treatments: Dietary Supplement: Orange flavoured water with maltodextrin as the placebo; Dietary Supplement: Mineral Rich Algae

Study type: Interventional

Funder types: Other

Identifiers

NCT03980678

AAPtrial

Details and patient eligibility

About

Deep ocean mineral water has been shown to improve exercise phenotypes in human and animal models. However, there is yet to be an investigation of Algae species such as Lithothamnion that absorb and concentrate these minerals. Therefore, the AAP trial will investigate the effect of water soluble Lithothamnion species on exhaustive exercise-induced blood lactate accumulation, recovery and power output in trained cyclists.

Full description

The potential for naturally derived combinations of marine minerals to improve exercise performance is growing throughout the scientific literature and has physiologically plausible mechanisms, likely through the diverse molecular and enzymatic actions of individual (or combinations of) minerals (such as Calcium and Magnesium).

Despite the biological potential, there is little consciences whether mineral supplementation can improving markers of, and exercise performance. One recent investigation of deep ocean mineral water (high in marine minerals) showed that when consumed prior to exercise, blood lactate response improved with hyperthermal running and is supported in animal models - however, this is not supported elsewhere in humans. Nonetheless, others have shown, in human models, that deep ocean mineral water may improve exercise recovery, aerobic exercise performance, improve lower leg power output and hydration status compared to either placebo or sports drink. Furthermore, animal models support these plausibilities with improved mitochondrial biogenesis, biomolecules of exercises performance, cardiovascular hemodynamics, inflammatory cytokine responses to exercise and overall exercise adaptation.

As ocean minerals are absorbed by marine organisms, Algae species such as Lithothamnion have higher concentrations of the same ocean minerals but structured differently at the nano scale and thus may have the potential to be more effective at improving exercise phenotypes. Therefore, the proposed exploratory RCT will investigate the effects of water soluble Lithothamnion species on exhaustive exercise-induced lactate accumulation, recovery and power output in trained cyclists, compared to a placebo.

Enrollment: 10 estimated patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male trained cyclist.
• Cycling for the purpose of exercise training (i.e. not cycling for transport) at least 100km per week for the last 6 months
• VȮ2peak that is greater than 50 ml˙kg˙ml-1

Exclusion criteria

• Any muscle disorder
• Serious medical co-morbidities
• Thyroid dysfunction or specific allergies
• Contraindications to dependent variables
• Currently participation in another research study
• Currently not talking other nutrition supplements

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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10 participants in 2 patient groups, including a placebo group

Mineral Rich Algae with orange flavoring

Active Comparator group

Description:

Participants will consume the Aquamin Soluble (Mineral Rich Algae) equivalent of 1000mg Calcium in 250 ml of orange flavoured water.

Treatment:

Dietary Supplement: Mineral Rich Algae

Water with orange flavoring

Placebo Comparator group

Description:

Participants will consume a placebo of maltodextrin in 250 ml of orange flavoured water (40mg Calcium).

Treatment:

Dietary Supplement: Orange flavoured water with maltodextrin as the placebo