Liver Diseases in PLWH

Zhejiang University

Status: Unknown

Conditions: HIV/AIDS; Liver Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT04446156

ZJHIVER

Details and patient eligibility

About

In Highly Active Antiretroviral Therapy era, fatty liver has become an important cause of liver function damage in people living with HIV (PLWH). There are a large number of PLWH in China who are infected with hepatitis B virus and hepatitis C virus. HIV, hepatitis B virus, hepatitis C virus, drugs, alcohol, etc. affect each other, which makes the cause, diagnosis, and treatment of liver function damage in PLWH complicated in China.

The investigators plan to conduct a large-scale questionnaire survey among PLWH in Zhejiang Province to assess liver function, detect liver Injuries early, and analyze HIV, hepatitis B virus, hepatitis C virus, anti-HIV drugs, alcohol and other factors associate with liver injuries in PLWH, to provide basis for the treatment and prevention of liver disease in PLWH in eastern China.

Enrollment: 3,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years old;
• Non-hospitalized patients diagnosed with HIV infection;
• Sign the informed consent voluntarily.

Exclusion criteria

• Severe active infection requiring parenteral antibiotics or antifungal treatment within 30 days before the assessment;
• Other major chronic diseases that may affect health-related quality of life, such as extrahepatic malignant tumors;
• Psychotic patients, patients with severe cognitive or neurological deficits;
• Women during pregnancy and lactation;
• Those who refuse to sign informed consent.