Liver Function Abnormalities in Patients With Acute Heart Failure

Sohag University

Status: Not yet enrolling

Conditions: Acute Heart Failure

Treatments: Behavioral: Avoiding the risk factors

Study type: Observational

Funder types: Other

Identifiers

NCT06491628

LFTs abnormalities in AHF

Details and patient eligibility

About

The aim of this study is to evaluate liver function test abnormalities and to identify associated cardiac and non cardiac factors mediating hepatic impairment in acute heart failure patients

Full description

Cardiac failure has a negative impact on the function of all parenchymatous organs, based both on the low organ perfusion in the left-sided failure and on the venous congestion in the right-sided failure.

The pathophysiology of acute heart failure (AHF) is complex and not fully understood. It has been hypothesized that an episode of acute decompensation affects not only the cardiovascular system itself, but may also deteriorate the function of other organs, c ausing serious clinical consequences. Liver involvement has been mostly described and investigated in patients with chronic HF.

Liver enzyme alterations are usually classified as relating predominantly to liver cell necrosis (signified by transaminase elevations) or predominantly to cholestasis (signified by elevated alkaline phosphatase (AP) level).

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged 18 yrs or older presenting with AHF

Exclusion criteria

• Congenital heart disease
• acute and chronic liver diseases

Trial design

100 participants in 5 patient groups

Acute decompensated heart failure (de novo or as decompensation of chronic heart failure)

Description:

This umbrella term includes patients presenting forthe first time with typical symptoms and signs of heart failure(de novo AHF) and also those with worsening of their pre-existing cardiomyopathy (acute decompensated heart failure).

Treatment:

Behavioral: Avoiding the risk factors

Pulmonary edema

Description:

It's the real clinical presentation of AHF, typically, signs and symptoms develope rapidly and patients demonstrate severe respiratory distress with tachypnea, orthopnea and pulmonary congestion

Treatment:

Behavioral: Avoiding the risk factors

Hypertensive acute heart failure

Description:

the condition is associated with elevated blood pressure with accompanying dyspnea. orthopnea and pulmonary congestion, often in patients with relatively preserved left ventricle ejection fraction

Treatment:

Behavioral: Avoiding the risk factors

cardiogenic shock

Description:

severe peripheral hypoperfusion wih subsequent end organs damage,typically it's associated with low blood pressure and low urine output

Treatment:

Behavioral: Avoiding the risk factors

Acute coronary syndrome complicated by heart failure

Description:

characterized by complex structural, hemodynamic and neurohormonal interaction need urgent referral for coronary intervention poor outcome

Treatment:

Behavioral: Avoiding the risk factors