Liver Glycogen Dynamics (LGD)

Maastricht University

Status

Completed

Conditions

Hepatic Glycogen

Treatments

Behavioral: Overnight fasting duration

Study type

Interventional

Funder types

Other

Identifiers

NL72118.068.20

Details and patient eligibility

About

The purpose of this study is to investigate the effect of prolonged overnight fasting in the hepatic glycogen stores

Enrollment

10 patients

Sex

All

Ages

45 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Participants are able to provide signed and dated written informed consent prior to any study specific procedures
Caucasian (people will be excluded when having a ≥50% racial African/Asian background)
Participants should have suitable veins for cannulation or repeated venipuncture
Women are post-menopausal (defined as at least 1 year post cessation of menses)
Men and women aged ≥ 45 and ≤ 75 years at the start of the study
Body mass index (BMI) 18.5 - 25 kg/m2
Stable dietary habits (no weight loss or gain >3kg in the past 3 months)
Sedentary lifestyle (not more than 3 hours of vigorous sports per week)

Exclusion criteria

Type 2 Diabetes Mellitus
Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
Any contraindication for MRI scanning
Alcohol consumption of >2 servings per day
Regular smoking
No use of medication interfering with investigated study parameters (as determined by responsible physician)
Participants who do not want to be informed about unexpected medical findings, or do not wish that their physician