Liver Health and Metabolic Function in People With Obesity

The Washington University

Status: Completed

Conditions: Non-Alcoholic Fatty Liver Disease

Treatments: Procedure: Weight loss surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT03701828

201808128

Details and patient eligibility

About

This project aims to determine the effect of significant weight loss on rates on hepatic fibrogenesis in people with obesity.

Full description

Non-alcoholic fatty liver disease (NAFLD) affects approximately 70% of those with obesity and if left untreated can progress to cirrhosis and liver failure. NAFLD stages progress from the stage of simple steatosis to steatohepatitis, and fibrosis The stage of NAFLD is currently best determined using histology from a liver biopsy, however this provides a static depiction of the state of the liver. Therefore, this project aims to determine fibrogenesis in the liver of obese humans in vivo, before and after weight loss.

Enrollment: 23 patients

Sex: All

Ages: 21 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index ≥35 kg/m2
• Scheduled for Bariatric surgery

Exclusion criteria

• Significant organ disfunction/disease
• Tobacco use
• Previous bariatric surgery
• Pregnancy
• Excessive alcohol use
• Liver disease other than NAFLD

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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23 participants in 1 patient group

Weight loss

Experimental group

Description:

Participants will undergo weight loss surgery

Treatment:

Procedure: Weight loss surgery