Liver Regeneration After Liver Resection

NHS Trust

Status: Unknown

Conditions: Hepatectomy; Liver Diseases

Treatments: Procedure: Liver biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT01220986

NDDC10/H0403/32

Details and patient eligibility

About

The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy. The investigators hypothesise that liver regeneration after right hepatectomy in humans is associated with Kupffer cell activation and initiation of the innate immune response and that impaired liver regeneration, liver failure and sepsis following liver resection are associated with Kupffer cell dysfunction and an impaired innate immune response. The objectives for this study are to characterise Kupffer cell activity and the innate immune response in human liver before and after right hepatectomy.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients requiring right hepatectomy for colorectal liver metastases

Exclusion criteria

• Age >75, neoadjuvant chemotherapy, recurrent disease

Trial design

20 participants in 1 patient group

Right hepatectomy

Description:

Intervals from inflow division.

Treatment:

Procedure: Liver biopsy