Liver Transplantation for Unresectable GIST Liver Metastases (TRANSGIST)

Virgen de la Arrixaca University Clinical Hospital (HCUVA)

Status: Not yet enrolling

Conditions: Liver Transplantation; Liver Transplant; Complications; Liver Transplant Disorder; Gastrointestinal Stromal Tumor of Duodenum; GIST, Malignant; Gastrointestinal Stromal Tumor of Rectum; Metastatic Liver Cancer; Liver Carcinoma; Gastrointestinal Stromal Tumor (GIST) of the Gastrointestinal Tract; Liver Cancer; Gastrointestinal Stromal Tumor, Unspecified Site; Liver Neoplasms; Metastases; Gastrointestinal Stromal Tumor of Stomach; GIST; Liver Diseases; Transplant Oncology; Metastases to Liver; Liver Mass; Gastrointestinal Stromal Tumor, Malignant; Metastasis; Liver Metastases; Gastrointestinal Stromal Tumor of Esophagus (Disorder); Gastrointestinal Stromal Tumors; Gastrointestinal Stromal Tumor by AJCC V8 Stage; Gastrointestinal Stromal Tumor of Large Intestine (Disorder); Gastrointestinal Stromal Tumor of Other Sites; Gastrointestinal Stromal Tumor of Small Intestine (Disorder)

Treatments: Procedure: Liver Transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT04825470

TRANSGIST

Details and patient eligibility

About

Liver Transplantation for Unresectable GIST Liver Metastases

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• GIST diagnosis (c-Kit, CD34, DOG-1)
• Imatinib-sensitive mutation
• Non-resectable liver metastases
• Abscence of extrahepatic disease
• Period greater than two years between primary tumor and metastases diagnosis

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Liver Transplantation

Experimental group

Treatment:

Procedure: Liver Transplantation