Living Donor Liver Transplant for Unresectable Colorectal Liver Metastases

University of Rochester

Status: Enrolling

Conditions: Colorectal Cancer Metastatic

Treatments: Procedure: Liver transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT05248581

STUDY00004076

Details and patient eligibility

About

The goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation.

Full description

The goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation.

Our primary outcome of interest was the OS and recurrence-free survival (RFS) of patients who underwent LDLT at our center.

Enrollment: 25 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18
• Non-amenable to curative hepatic resection as defined by FLR <30%
• Histologically confirmed adenocarcinoma of the colon or rectum
• Candidate for LDLT for colorectal liver metastasis per the University of Rochester liver transplant program

Exclusion criteria

• Not a candidate of the LDLT liver transplant protocol for treatment of colorectal liver metastasis.
• Unwilling to consent

Trial design

25 participants in 1 patient group

All Participants

Description:

Potential subjects for this registry must have Stage IV colorectal cancer with liver metastases and be candidates for liver transplantation based on multidisciplinary discussion by the Liver transplantation team. Patients must demonstrate favorable tumor biology and no evidence of extra hepatic disease.

Treatment:

Procedure: Liver transplantation