Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases

University Health Network, Toronto

Status

Enrolling

Conditions

Liver Metastases

Colorectal Cancer

Treatments

Procedure: live donor liver transplantation

Study type

Interventional

Funder types

Other

Identifiers

NCT02864485

15-9382-C

Details and patient eligibility

About

Patients with unresectable liver metastases (LM) from colorectal cancer (CRC)have a poor prognosis. In patients with resectable disease, surgery offers a distinct survival benefit. This study will offer live donor liver transplantation (LDLT) to select patients with unresectable metastases that are 1) limited to the liver and 2) stable (non-progressing) on standard chemotherapy. Potential participants will be evaluated for liver transplant suitability and must also have a willing, healthy living donor come forward for evaluation. Those participants who undergo LDLT will be followed for survival, disease-free survival and quality of life for 5 years and compared to a "control group" of participants who drop out of study prior to transplantation due to reasons other than cancer progression.

Full description

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Approximately half of all patients develop metastases, often to the liver or lung. Surgical treatment of liver metastases (LM) is the only curative treatment option; however, it has been estimated that only 20-40% of patients are candidates for liver resection. Surgery offers a distinct survival advantage: the 5-year survival after liver resection for LM is around 40-50% in most studies versus 10-20% 5-year survival for chemotherapy alone.

In cases where the colorectal metastases are isolated to the liver but "unresectable", the total hepatectomy resulting from liver transplantation would remove all evident disease. CRC LM are considered an absolute contraindication for liver transplantation (LT) at most centers but recent reports of LT for colorectal LM from a single center in Oslo, Norway demonstrated a 5-year survival of 56%. The Norway study was not stringent about inclusion criteria or pre-transplant chemotherapy, and transplanted patients whose tumors were actively growing. As a result many participants developed disease recurrence quite rapidly following transplant. The investigators hypothesize that tighter criteria would result in improved outcomes.

Unfortunately, with a lack of deceased donor grafts for the investigators existing transplant patients, the investigators cannot utilize decease donor grafts for this study. Therefore the investigators will explore Living Donor Liver Transplantation (LDLT). Furthermore, LDLT is an elective surgery, allowing for more control over pre-transplant chemotherapy and tumor monitoring. This study will offer live donor liver transplantation (LDLT) to select patients with unresectable metastases that are 1) limited to the liver and 2) stable (non-progressing) on standard chemotherapy. Potential participants will be evaluated for liver transplant suitability and must also have a willing, healthy living donor come forward for evaluation. Those participants who undergo LDLT will be followed for survival, disease-free survival and quality of life for 5 years and compared to a "control group" of participants who drop out of study prior to transplantation due to reasons other than cancer progression.

Enrollment

20 estimated patients

Sex

All

Ages

18 to 68 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Must reside in Canada
ECOG ( Eastern Cooperative Oncology Group) score : 0-1 at all times prior to LDLT (excursions to ECOG 2 allowed at investigator's discretion)
Proven colorectal Liver Metastases (LM).
Willing and able to provide written informed consent.
Negative serum pregnancy test for women of childbearing potential
Both men and women must agree to use adequate barrier birth control measures during the course of the trial.
At least 1 "acceptable", ABO-compatible living donor has stepped forward
Primary Colorectal cancer tumor stage is ≤T4a
Time from primary CRC resection to transplant is ≥6 months
Bilateral and non-resectable LM
No major vascular invasion by LM; metastases isolated to liver
The patient has undergone systemic chemotherapy (eg. FOLFOX +/- bevacizumab or FOLFIRI +/- bevacizumab) for ≥3 months
demonstrated stability or regression of LM over at minimum the 3 months preceding screening
Carcinoembryonic Antigen (CEA) values are stable or decreasing at all timepoints prior to the transplant surgery.

Exclusion criteria

Previous or concurrent cancer (with some exceptions)
prior lung resection
Progression of LM at any timepoint prior to transplant surgery
Renal dysfunction with an estimated creatinine clearance of less than 50 ml/min
Pulmonary insufficiency
History of cardiac disease
Known history of human immunodeficiency virus (HIV) infection or chronic hepatitis B and/or C infection.
Patients with debilitating neuropathy. (CTCAE > grade 2)
BRAF + tumors
Any condition that is unstable or which could jeopardize the safety of the patient and his/her compliance in the study