Local Anaesthetic for Transvaginal Egg Collection in IVF

The Fertility Centre, New Zealand

Status: Completed

Conditions: Infertility

Treatments: Drug: normal saline; Drug: lignocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT00554424

01/12/180

Details and patient eligibility

About

The purpose of this study is to see whether injecting local anaesthetic into the vaginal tissues,just prior to transvaginal egg collection,will decrease the amount of pain experienced by women having their eggs collected on an IVF cycle. All women will also receive intravenous sedation as required as well as a sleeping tablet thirty minutes prior to the procedure which is our routine procedure for egg collection.

Full description

Transvaginal oocyte retrieval is the most common method of oocyte collection in IVF cycles. A variety of different methods are used to provide analgesia/anesthesia for oocyte collection. Our unit has always used an oral pre-medication followed by intravenous fentanyl during the procedure but this doesn't seem to provide adequate analgesia for some women. The aim of this study was to compare the addition of intravaginal local anaesthetic injection versus saline placebo to our usual analgesia regime to see whether less intravenous fentanyl was required and whether the women experienced less pain during oocyte collection.

Enrollment: 75 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• About to undergo transvaginal oocyte retrieval

Exclusion criteria

• Already undergone oocyte retrieval and participated in study (i.e. 2nd or more oocyte collection procedure during study period)
• Allergy to lignocaine
• Oocytes only to be collected from one ovary
• Procedure expected to be exceptionally painful

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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75 participants in 2 patient groups, including a placebo group

LA

Active Comparator group

Description:

Intravaginal and pre-peritoneal injection of 1% lignocaine into each side of the upper vagina under ultrasound guidance immediately prior to ultrasound guided transvaginal oocyte retrieval

Treatment:

Drug: lignocaine

P

Placebo Comparator group

Description:

Intravaginal saline placebo injection into each side of upper vagina under ultrasound guidance immediately prior to transvaginal oocyte retrieval

Treatment:

Drug: normal saline