Local and Systemic Changes in Osteonecrosis of the Jawbone (SULVO)

Medical University of Graz

Status: Invitation-only

Conditions: Osteonecrosis of the Jaw

Study type: Observational

Funder types: Other

Identifiers

NCT05329558

30-196 ex 17/18

Details and patient eligibility

About

Osteonecrosis of the Jawbone (ONJ) is a serious complication of antiresorptive therapies (ARTs), for example with bisphosphonates or Denosumab. Especially long term treatment with intravenous antiresorptive agents causing lesions and, less frequent, also oral administration. This study aims at elucidating local and systemic changes in patients with ONJ.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years or older
• with/without ART
• with/without MRONJ

Exclusion criteria

• smoker (>10 cigarettes/day)
• pregnancy

Trial design

100 participants in 4 patient groups

Healthy Controls

Patients with ART without MRONJ

Patients with oral ART with MRONJ

Patients with intravenous ART with MRONJ