Local Infiltration Analgesia in Bilateral Knee Arthroplasty - Efficacy of Subcutaneous Wound Infiltration With Local Anesthetic

Hvidovre University Hospital

Status and phase: Completed; Phase 4

Conditions: Pain, Postoperative

Treatments: Drug: ropivacaine 0.2%, 50 mL; Drug: normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT00927225

H-D-2008-104

Details and patient eligibility

About

Local infiltration analgesia is effective in total knee arthroplasty for postoperative pain management, but the efficacy of subcutaneous wound infiltration has not been evaluated. This study aims at evaluating the efficacy of subcutaneous wound infiltration in total knee arthroplasty in 16 patients undergoing bilateral knee arthroplasty.

Enrollment: 16 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• total bilateral knee arthroplasty

Exclusion criteria

• immunological diseases
• treatment with opioids or steroids
• allergy to any drugs administered

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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16 participants in 2 patient groups, including a placebo group

active

Active Comparator group

Description:

subcutaneous wound infiltration with 50 mL ropivacaine 0.2%

Treatment:

Drug: ropivacaine 0.2%, 50 mL

placebo

Placebo Comparator group

Description:

subcutaneous wound infiltration with 50 mL saline

Treatment:

Drug: normal saline