Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue

Esben Thyssen Vestergaard

Status and phase: Completed; Early Phase 1

Conditions: Healthy

Treatments: Drug: Placebo (Ringer acetate); Drug: Acyl ghrelin

Study type: Interventional

Funder types: Other

Identifiers

NCT01595373

2012-28512

Details and patient eligibility

About

The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.

Enrollment: 10 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy male
• age 18-65 years (included)
• Body mass index 20-25 (included)

Exclusion criteria

• alcohol abuse
• malignant disease
• use of any medicine except otc painkillers
• any disease recognized
• participation in a trial using radioactive isotopes within the last 6 months

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 2 patient groups, including a placebo group

Ghrelin

Active Comparator group

Description:

Ghrelin

Treatment:

Drug: Acyl ghrelin

Placebo

Placebo Comparator group

Description:

Ringer acetate is used for placebo.

Treatment:

Drug: Placebo (Ringer acetate)