Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE)

The Chinese University of Hong Kong

Status

Invitation-only

Conditions

Aging

Dementia Frontotemporal

Parkinson Disease

Depression in Old Age

Dementia Alzheimers

Treatments

Device: Transcranial Magnetic Stimulation

Study type

Observational

Funder types

Other

Identifiers

NCT05967390

2018.077 (Other Identifier)

Details and patient eligibility

About

Scalp to cortex distance (SCD), as a key technological parameter of brain stimulation, has been highlighted in the guidelines of non-invasive brain stimulation. However, in the context of age-related brain changes, the region-specific SCD and its impact on stimulation-induced electric field in different types of neurodegenerative diseases remain unclear.

Full description

Objective: This study aimed to investigate the region-specific SCD and its relationship with morphometric features and cognitive function in age- and disease-specific populations. Methods: The SCD and cortical thickness (CT) of left primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) were measured in cognitively normal adults and dementia patients. CT-adjusted SCD was used to control the influence of CT on SCD. Head model was developed to simulate the impact of SCD on the electric field induced by transcranial electrical stimulation.

Enrollment

488 estimated patients

Sex

All

Ages

60 to 95 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Right-handed as assessed by the Edinburgh Inventory
Able to attend TMS interventions
Consent
Independent in daily life activities

Exclusion criteria

Uncorrected visual or auditive deficits not allowing the realization of the test
Evolutive disease (such as cancer)
Neurological or psychiatric antecedent
Counter-indication to MRI