Lock sOlutiOnS for Epicutaneo-caval Catheters in Neonates: a "LOOSEN" Pilot Study

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Preterm; Catheter-related Bloodstream Infection; Catheter Complications; Catheter Infection

Treatments: Combination Product: neutrox

Study type: Observational

Funder types: Other

Identifiers

NCT05729321

4880

Details and patient eligibility

About

Epicutaneo-caval catheters (ECCs) are widely used in neonatal intensive care units (NICUs). They are small catheters inserted via superficial veins of the limbs or scalp using direct vein visualization The pathogenic microorganisms colonized inside catheters can easily form a bacterial biofilm and eventually spread with blood flow which causes bloodstream infection. Many authors have studied the antibiotic-lock therapy (ALT) in which a high-dose antibiotic solution is dripped and maintained in the catheter cavity for a certain period and can dissolve the biofilm formed on the wall to reduce the colonization of the bacteria and kill the embedded bacteria.The aim of the study is to evaluate the patency of the Epicutaneo-caval catheter after its closure for 1 hour.

Enrollment: 7 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

All the Epicutaneo-caval catheter that need to be removed electively will be included in the study -

Exclusion criteria

All the Epicutaneo-caval catheters removed not electively but for infectious or mechanical complications will be excluded from the study.

Trial design

7 participants in 1 patient group

Epicutaneo-caval catheter removed electively

Description:

This is a pilot study designed to evaluate the patency of the Epicutaneo-caval catheter after its closure for 1 hour in order to assess the feasibility of possible Taurolidine lock-terapy in Epicutaneo-Caval Catheters.

Treatment:

Combination Product: neutrox