LOD Before IVF/ICSI in PCOS Patients With High AMH

Mansoura University

Status: Completed

Conditions: Infertility; Polycystic Ovarian Syndrome

Treatments: Procedure: LOD

Study type: Observational

Funder types: Other

Identifiers

NCT03358199

MSA6

Details and patient eligibility

About

To evaluate the effect of performing laparoscopic ovarian drilling (LOD) before proceeding to in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) on the cycle outcomes in polycystic ovarian syndrome (PCOS) patients with high antimullerian hormone (AMH) levels

Full description

Retrospective case-control study of PCOS women with high serum AMH level (≥ 7 ng/ml) who were subjected IVF/ICSI. Women underwent LOD in the preceding 3 months prior to IVF/ICSI (study group) will be compared with a control group of women who did not underwent LOD (control group)

Enrollment: 120 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• PCOS women subjected to COS through fixed gonadotropin releasing hormone (GnRH) antagonist protocol with final triggering of oocyte maturation by GnRH agonist (GnRHa)
• Elevated serum AMH level (≥ 7 ng/ml)

Exclusion criteria

• Age < 18 years or > 35 years
• Body mass index (BMI) < 19 kg/m2 or > 35 kg/m2
• Use of cabergoline therapy or coasting to minimize the risk of OHSS

Trial design

120 participants in 2 patient groups

Study group

Description:

PCOS women with AMH level (≥ 7 ng/ml) who underwent LOD in the preceding 3 months prior to IVF/ICSI

Treatment:

Procedure: LOD

Control group

Description:

PCOS women with AMH level (≥ 7 ng/ml) who did not undergo LOD in the preceding 3 months prior to IVF/ICSI