Long Sleep Duration and Vascular Function

Texas Tech University

Status: Completed

Conditions: Sleep

Treatments: Behavioral: Sleep duration

Study type: Interventional

Funder types: Other

Identifiers

NCT04679051

19IPLOI34760579

Details and patient eligibility

About

Sleep duration has received much attention in recent years due to strong evidence that not enough sleep can increase risk for a number of diseases and disorders. Research is emerging that too much sleep also has a negative impact on health, particularly higher risk for myocardial infarction and stroke. The investigators hypothesize that long duration sleep has the ability to impair peripheral and cerebral vascular function in middle-aged to older adults.

Full description

The aim of this study is to compare the effect of long duration sleep (>9 hours) to recommended levels of sleep (7-8 hours) in a crossover designed study requiring adults to maintain each prescribed sleep duration for one week. Ambulatory brachial and central aortic blood pressure will be measured during sleep, while cerebrovascular reactivity, carotid artery hemodynamics (e.g., flow pulsatility), aortic pulse wave reflections, cognitive function, and peripheral vasodilatory function will be measured before and after each sleep protocol. A secondary objective of this study is to understand whether aerobic exercise can improve vascular function under conditions of different sleep durations. This information will shed light upon the impact of sleep parameters on exercise-induced improvements in vascular function.

Enrollment: 23 patients

Sex: All

Ages: 40 to 79 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• recreationally active
• reporting no recent history of sleep problems
• not taking sleep-inducing medication
• not diabetic (fasting blood glucose <126 mg/dL)

Exclusion criteria

• show symptoms of insomnia
• smoke
• have a personal history of stroke or diabetes
• take birth control pills

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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23 participants in 2 patient groups

8 hours time in bed

Experimental group

Description:

Participants will be asked to spend 8 hours time in bed with the aim of achieving one week of normal sleep duration (7 to 8 hours).

Treatment:

Behavioral: Sleep duration

11 hours time in bed

Experimental group

Description:

Participants will be asked to spend 11 hours time in bed with the aim of achieving one week of long duration sleep as defined as 9+ hours of sleep.

Treatment:

Behavioral: Sleep duration