Long-Standing Persistant Atrial Fibrillation-Pulmonary Vein Isolation With or Without Ablation (Alster-Lost)

Asklepios proresearch

Status: Completed

Conditions: Atrial Fibrillation; Tachycardia

Treatments: Procedure: pulmonary vein isolation; Procedure: pulmonary vein isolation with additional ablation of fragmented potentials

Study type: Interventional

Funder types: Industry

Identifiers

NCT00820625

PV 2961 (Other Identifier)

1787

Details and patient eligibility

About

The chronic success rate, defined as freedom from any atrial tachyarrhythmias will increase from 35% to 60% by ablation of complex fragmented atrial electrograms potentials in addition to pulmonary vein isolation (PVI) as compared to PVI alone in patients with long-standing persistent AF.

Enrollment: 124 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• long standing persistent atrial fibrillation > 6 months and < 5 years

Exclusion criteria

• renal failure
• left atrial size >55 mm

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

124 participants in 2 patient groups

1

Active Comparator group

Description:

ablation: pulmonary vein isolation

Treatment:

Procedure: pulmonary vein isolation

2

Active Comparator group

Description:

ablation: pulmonary vein isolation with additional ablation of fragmented potentials

Treatment:

Procedure: pulmonary vein isolation with additional ablation of fragmented potentials