Long-term Assessment of Organ Functions Among Survivors of Severe Acute Respiratory Syndrome

Peking University

Status: Unknown

Conditions: Long-Term Survivors; SARS Virus

Study type: Observational

Funder types: Other

Identifiers

NCT03443102

2018PHB010-01

Details and patient eligibility

About

SARS-CoV has caused severe epidemic respiratory disease in human populations. By July 2003, a total of 8,096 probable cases of SARS had been reported including 774 deaths in 27 countries, around one-third of which were health care workers (HCWs). Previous studies have been reported about long-term impacts of SARS infection, including lung function deficiency, steroid-induced osteonecrosis, reduced exercise capacity, and impairment in health-related quality of life (HRQoL). HCWs, especially nurses, have been reported to experience greater psychological distress, particularly increased levels of posttraumatic stress symptomatology (PTSS). But the very complex impacts of this fatal infection on HCWs have not been fully elucidated. It is thus important to follow these occupational patients to detect and manage multi-organ sequelae and functional impairment.

Enrollment: 150 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Health care workers who were working at Peking University People's Hospital during the SARS epidemic in 2002-2003

Exclusion criteria

• Refusal to continue the study

Trial design

150 participants in 2 patient groups

SARS survivors

Description:

First-line HCWs infected during the SRAS-CoV pandemic in Peking University People's Hospital, China. Diagnose was further confirmed by SARS-CoV seropositive results.

Controls

Description:

1. Coworkers of the infected HCWs, who also exposed to SARS patients or specimens. Infection was further excluded by SARS-CoV seronegative results. 2. Healthy controls matched for age, sex and disease condition, but without exposures to SARS virus.