Long-term Caloric Restriction and Cellular Aging Markers (CRONA)

University of California San Francisco (UCSF)

Status: Completed

Conditions: Aging

Study type: Observational

Funder types: Other

Identifiers

NCT01256840

UCSF-CHR-10-01323

Details and patient eligibility

About

The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.

Enrollment: 71 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Calorie restricting group: Self-reported caloric restriction for at least two years
• Calorie restriction group: BMI below 23
• Normal eating control: Normal eating (no history of caloric restriction) for two years
• Normal eating control: BMI below 30
• Obese comparison group: BMI above 30
• Obese comparison group: Normal eating (no history of caloric restriction) for two years

Exclusion criteria

• Regular smoker for the past six months

Trial design

71 participants in 3 patient groups

Calorie Restricting Group

Normal-eating controls

Obese comparison group